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ASM Antimicrobial Agents and Chemotherapy Applied and Environmental Microbiology Clinical Microbiology Reviews Clinical and Vaccine Immunology EcoSal Plus Eukaryotic Cell Infection and Immunity Journal of Bacteriology Journal of Clinical Microbiology Journal of Microbiology & Biology Education Journal of Virology mBio Microbiology and Molecular Biology Reviews Microbiology Resource Announcements Microbiology Spectrum Molecular and Cellular Biology mSphere mSystems Log in My alerts My CartHome Articles Current Issue Accepted Manuscripts Archive Minireviews For Authors Submit a Manuscript Scope Editorial Policy Submission, Review, & Publication Processes Organization and Format Errata, Author Corrections, Retractions Illustrations and Tables Nomenclature Abbreviations and Conventions Publication Fees Ethics Resources and Policies About the Journal About AAC Editor in Chief Editorial Board For Reviewers For the Media For Librarians For Advertisers Alerts RSS FAQ Subscribe Members Institutions ASM Antimicrobial Agents and Chemotherapy Applied and Environmental Microbiology Clinical Microbiology Reviews Clinical and Vaccine Immunology EcoSal Plus Eukaryotic Cell Infection and Immunity Journal of Bacteriology Journal of Clinical Microbiology Journal of Microbiology & Biology Education Journal of Virology mBio Microbiology and Molecular Biology Reviews Microbiology Resource Announcements Microbiology Spectrum Molecular and Cellular Biology mSphere mSystems User menu Log in My alerts My Cart Search Search for this keyword Advanced search Search for this keyword Advanced Search Home Articles Current Issue Accepted Manuscripts Archive Minireviews For Authors Submit a Manuscript Scope Editorial Policy Submission, Review, & Publication Processes Organization and Format Errata, Author Corrections, Retractions Illustrations and Tables Nomenclature Abbreviations and Conventions Publication Fees Ethics Resources and Policies About the Journal About AAC Editor in Chief Editorial Board For Reviewers For the Media For Librarians For Advertisers Alerts RSS FAQ Subscribe Members Institutions Identification of Drug Resistance Determinants in a Clinical Isolate of Pseudomonas aeruginosa by High-Density Transposon Mutagenesis Penetration of Ibrexafungerp (Formerly SCY-078) at the Site of Infection in an Intra-abdominal Candidiasis Mouse Model 1 2 Current Issue Accepted Manuscripts Commentary Free Editor’s Pick Commentary A Unified Numbering Scheme for Class C β-Lactamases A standard numbering scheme has been proposed for class C β-lactamases. This will significantly enhance comparison of biochemical and biophysical studies performed on different members of this class of enzymes and facilitate communication in the field. Malcolm G. P. Page Minireviews Minireview 100 Years of Suramin Suramin is 100 years old and is still being used to treat the first stage of acute human sleeping sickness, caused by Trypanosoma brucei rhodesiense . Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite, and autism. Natalie Wiedemar , Dennis A. Hauser , Pascal Mäser Minireview Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions Many antibiotics carry caution stickers that warn against alcohol consumption. Data regarding concurrent use are sparse. An awareness of data that address this common clinical scenario is important so health care professionals can make informed clinical decisions and address questions in an evidence-based manner. The purpose of this systematic review was to determine the evidence behind alcohol warnings issued for many common... Kari A. Mergenhagen , Bethany A. Wattengel , Megan K. Skelly , Collin M. Clark , Thomas A. Russo Minireview Carbapenem-Resistant Gram-Negative Bacterial Infections in Children Carbapenem-resistant organisms (CRO) are a major global public health threat. Enterobacterales hydrolyze almost all β-lactams through carbapenemase production. Infections caused by CRO are challenging to treat due to the limited number of antimicrobial options. This leads to significant morbidity and mortality. Over the last few years, several new antibiotics effective against CRO have been approved. David Aguilera-Alonso , Luis Escosa-García , Jesús Saavedra-Lozano , Emilia Cercenado , Fernando Baquero-Artigao Challenging Clinical Case in Antimicrobial Resistance Free Editor’s Pick Challenging Clinical Case in Antimicrobial Resistance Emergence of Ceftriaxone Resistance during a Case of Pneumococcal Meningitis with Fatal Evolution We report a case of a 62-year-old man treated for Streptococcus pneumoniae meningitis by ceftriaxone and dexamethasone. After neurological improvement, neurological degradation by vasculitis occurred, despite effective concentrations of ceftriaxone in the serum and cerebrospinal fluid (CSF). S. pneumoniae... A. Mizrahi , J. C. Marvaud , B. Pilmis , J. C. Nguyen Van , C. Couzigou , C. Bruel , N. Engrand , A. Le Monnier , T. Lambert Free Editor’s Pick Challenging Clinical Case in Antimicrobial Resistance Case Commentary: Delayed Cerebral Vasculitis Associated with the Development of Ceftriaxone-Resistant Pneumococcal Meningitis Mizrahi and colleagues present a well-described case of the emergence of drug resistance in Streptococcus pneumoniae meningitis during therapy with ceftriaxone monotherapy with a low bactericidal concentration in the cerebrospinal fluid. Adherence to international guidelines could possibly have prevented the emergence of this resistant isolate and the adverse outcome... Rodrigo Hasbun Mechanisms of Action: Physiological Effects Open Access Mechanisms of Action: Physiological Effects Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling Antimicrobial resistance (AMR) is an ever-growing public health problem worldwide. The low rate of antibiotic discovery coupled with the rapid spread of drug-resistant bacterial pathogens is causing a global health crisis. To facilitate the drug discovery processes, we present a large-scale study of reference antibiotic challenge bacterial transcriptome profiles, which included 37 antibiotics across 6 mechanisms of actions (MOAs) and... Aubrie O’Rourke , Sinem Beyhan , Yongwook Choi , Pavel Morales , Agnes P. Chan , Josh L. Espinoza , Chris L. Dupont , Kirsten J. Meyer , Amy Spoering , Kim Lewis , William C. Nierman , Karen E. Nelson Editor’s Pick Mechanisms of Action: Physiological Effects Impact of Candida auris Infection in a Neutropenic Murine Model Candida auris has become a global public health threat due to its multidrug resistance and persistence. Currently, there are limited murine models to study C. auris infection. Those models use a combination of cyclophosphamide and cortisone acetate, suppressing both innate and adaptive immunity.... Steven R. Torres , Amber Pichowicz , Fernando Torres-Velez , Renjie Song , Navjot Singh , Erica Lasek-Nesselquist , Magdia De Jesus Mechanisms of Action: Physiological Effects Whole-Genome Approach to Understanding the Mechanism of Action of a Histatin 5-Derived Peptide The incidence of opportunistic fungal infections that threaten immunocompromised patients, along with the limited arsenal of antifungal drugs, calls for renewed efforts to develop novel antifungal therapies. Antimicrobial peptides have garnered interest as potential therapeutics. Among naturally occurring peptides, histatin 5 is a well-characterized 24-amino-acid peptide with strong antifungal activity. Cody B. Bullock , David S. McNabb , Inés Pinto Mechanisms of Action: Physiological Effects Subinhibitory Concentrations of Mupirocin Stimulate Staphylococcus aureus Biofilm Formation by Upregulating cidA Previous studies have shown that the administration of antibiotics at subinhibitory concentrations stimulates biofilm formation by the majority of multidrug-resistant Staphylococcus...